Research articles |
Reviews |
Book chapters |
2023
Alings F, Scharmann K, Eggers C, Böttcher B, Sokołowski M, Shvetsova E, Sharma P, Roth J, Rashiti L, Glatt S, Brunke S, Leidel SA.
Ncs2* mediates in vivo virulence of pathogenic yeast through sulphur modification of cytoplasmic transfer RNA.
Nucleic Acids Research 2023; In press. doi: 10.1093/nar/gkad564.
Meindl A, Romberger M, Lehmann G, Eichner N, Kleemann L, Wu J, Danner J, Boesl M, Mesitov M, Meister G, König J, Leidel SA, Medenbach J.
A rapid protocol for ribosome profiling of low input samples.
Nucleic Acids Research 2023; 51(13): e68. doi: 10.1093/nar/gkad459.
Günl F, Krischuns T, Schreiber J, Henschel L, Wahrenburg M, Drexler H, Leidel SA, Cojocaru V, Seebohm G, Mellmann A, Schwemmle M, Ludwig S, Brunotte L.
The ubiquitination landscape of the Influenza A Virus polymerase.
Nature Communications 2023; 14(1): 878. doi: 10.1038/s41467-023-36389-0.
2022
Leiva, Lorenzo Eugenio; Elgamal, Sara; Leidel, Sebastian A; Orellana, Omar; Ibba, Michael; Katz, Assaf.
Oxidative stress strongly restricts the effect of codon choice on the efficiency of protein synthesis in Escherichia coli.
Frontiers in Microbiology, 13(1042675), S. 1042675. doi: 10.3389/fmicb.2022.1042675.
Ravichandran, Keerthiraju E; Kaduhr, Lars; Skupien-Rabian, Bozena; Shvetsova, Ekaterina; Sokołowski, Mikołaj; Krutyhołowa, Ros Cisław; Kwasna, Dominika; Brachmann, Cindy; Lin, Sean; Guzman Perez, Sebastian; Wilk, Piotr; Kösters, Manuel; Grudnik, Przemysław; Jankowska, Urszula; Leidel, Sebastian A; Schaffrath, Raffael; Glatt, Sebastian.
E2/E3-independent ubiquitin-like protein conjugation by Urm1 is directly coupled to cysteine persulfidation.
EMBO journal, 41(20), S. e111318. doi: 10.15252/embj.2022111318.
2021
Puneet S, Wu J, Nilges BS, Leidel SA.
Humans and other commonly used model organisms are resistant to cycloheximide-mediated biases in ribosome profiling experiments.
Nature Communications 2021 Aug 24;12(1):5094. doi: 10.1038/s41467-021-25411-y.
Malecki J, O’Donohue MF, Kim Y, Jakobsson M, Gessa L, Pinto R, Wu J, Davydova E, Moen A, Olsen J, Thiede B, Gleizes PE, Leidel SA, Falnes P.
Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function.
Nucleic Acids Research 2021 Apr 6;49(6):3185-3203. doi: 10.1093/nar/gkab088.
Schulze S, Igiraneza AB, Kösters M, Leufken J, Leidel SA, Garcia BA, Fufezan C, Pohlschroder M.
Enhancing Open Modification Searches via a Combined Approach Facilitated by Ursgal.
Journal of Proteome Research 2021 Apr 2;20(4):1986-1996. doi: 10.1021/acs.jproteome.0c00799.
Kösters M, Leufken J, Leidel SA.
SMITER—A Python Library for the Simulation of LC-MS/MS Experiments.
Genes 2021, 12(3), 396.
2020
Renner H, Grabos M, Becker KJ, Kagermeier TE, Wu J, Otto M, Peischard S, Zeuschner D, Tsytsyura Y, Disse P, Klingauf J, Leidel SA, Seebohm G, Schöler HR, Bruder JM.
A fully automated high throughput workflow for 3D-based drug screening in human midbrain organoids.
eLife 2020; 9: e52904.
Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Schöler HR, Leidel SA, Bedzhov I.
Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during embryonic diapause.
Nature Communications 2020; 11(1): 5499.
Leiva LE, Pincheira A, Elgamal S, Kienast SD, Bravo V, Leufken J, Gutierrez DV, Leidel SA, Ibba M, Katz A.
Modulation of Escherichia coli translation by the specific inactivation of tRNAGly under oxidative stress.
Frontiers in Genetics 2020; 11: 856.
Pabis M*, Termathe M*, Ravichandran KE*, Kienast SD, Krutyhołowa R, Sokołowski M, Jankowska U, Grudnik P, Leidel SA**, Glatt S**.
Molecular basis for the bifunctional Uba4-Urm1 sulfur relay system in tRNA thiolation and ubiquitin-like conjugation.
EMBO Journal 2020; 39(19): e105087.
Haas A, Nilges BS, Leidel SA, Klempnauer KH.
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs.
Scientific Reports 2020; 10(1):2758.
Pinto R, Vågbø CB, Jakobsson ME, Kim Y, Wu J, Baltissen MP, O’Donohue MF, Guzmán UH, Kirpekar F, Małecki J, Olsen JV, Gleizes PE, Vermeulen M, Leidel SA, Slupphaug G, Falnes P.
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Nucleic Acids Research 2020; 48(2): 830-846.
2019
Lorent J, Kusnadi EP, van Hoef V, Rebello RJ, Leibovitch M, Ristau J, Chen S, Lawrence MG, Szkop KJ, Samreen B, Balanathan P, Rapino F, Close P, Bukczynska P, Scharmann K, Takizawa I, Risbridger GP, Selth LA, Leidel SA, Lin Q, Topisirovic I, Larsson O, Furic L.
Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression.
EMBO Journal 2019; 38: e101323.
Jacob D, Thüring K, Galliot A, Marchand V, Galvanin A, Ciftci A, Scharmann K, Stock M, Roignant JY, Leidel SA, Motorin Y, Schaffrath R, Klassen R, Helm M.
Absolute quantification of noncoding RNA by microscale thermophoresis.
Angewandte Chemie International Edition 2019; 58(28): 9565-9569.
Blasco-Moreno B, De Campos-Mata Leire, Boëttcher R, García-Martínez J, Jungfleisch J, Nedialkova DD, Chattopadhyay S, Oliva B, Pérez-Ortín JE, Leidel SA, Choder M, Díez J.
Xrn1 links mRNA synthesis, translation and decay.
Nature Communications 2019; 10(1): 1298.
de Crécy-Lagard V**, Boccaletto P, Mangleburg CG, Sharma P, Lowe TM**, Leidel SA**, Bujnicki JM**.
Matching tRNA modifications in humans to their known and predicted enzymes.
Nucleic Acids Research 2019; 47(5): 2143-2159.
2018
Taudière A, Bellanger JM, Carcaillet C, Hugot L, Kjellberg F, Lecanda A, Lesne A, Moreau PA, Scharmann K, Leidel SA, Richard F.
Diversity of foliar endophytic ascomycetes in the endemic Corsican pine forests.
Fungal Ecology 2018; 36: 128-140.
Rode S, Ohm H, Anhäuser L, Wagner M, Rosing M, Deng X, Sin O, Leidel SA, Storkebaum E, Rentmeister A, Zhu S, Rumpf S.
Differential Requirement for Translation Initiation Factor Pathways During Ecdysone-Dependent Neuronal Remodeling in the Drosophila PNS in Drosophila.
Cell Reports 2018; 24(9): 2287-2299.e4.
Sarin LP*, Kienast SD*, Leufken J, Ross RL, Dziergowska A, Debiec K, Sochacka E, Limbach PA, Fufezan C, Drexler HCA, Leidel SA.
Nano LC-MS using capillary columns enables accurate quantification of modified ribonucleosides at low femtomol levels.
RNA 2018; 24(10): 1403-1417.
Jakobsson ME, Małecki JM, Halabelian L, Nilges BS, Pinto R, Kudithipudi S, Munk S, Davydova E, Zuhairi FR, Arrowsmith CH, Jeltsch A, Leidel SA, Olsen JV, Falnes PØ.
The dual methyltransferase METTL13 targets N-terminus and Lys55 of eEF1A and modulates codon-specific translation rates.
Nature Communications 2018; 9(1): 3411.
Termathe M and Leidel SA.
A thioester intermediate via the E1-like activating protein Uba4 is required for thiocarboxylation of Urm1 and tRNA thiolation.
Nucleic Acids Research 2018; 46(10): 5171-5181.
Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G, Leucci E, Dewaele M, Vooijs M, Leidel SA, Georges M, Voz M, Peers B, Büttner R, Marine JC, Chariot A, Close P.
Codon-specific translation reprogramming promotes resistance to targeted therapy.
Nature 2018; 558(7711): 605-609.
Hartstock K, Nilges BS, Ovcharenko A, Cornelissen N, Püllen N, Lawrence-Dörner A, Leidel SA, Rentmeister A.
Enzymatic or in vivo installation of propargyl groups in combination with click chemistry enables enrichment and detection of methyltransferase target sites in RNA.
Angewandte Chemie International Edition 2018; 57(21): 6342-6346.
Bianchi S, Rogala KB, Dynes NJ, Hilbert M, Leidel SA, Steinmetz MO, Gönczy P, Vakonakis I.
Interaction between the C. elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly.
Molecular Biology of the Cell 2018; 29(6): 722-735.
Kösters M, Leufken J, Schulze S, Sugimoto K, Klein J, Zahedi RP, Hippler M, Leidel SA, Fufezan C.
pymzML v2.0: introducing a highly compressed and seekable gzip format.
Bioinformatics 2018; 34(14): 2513-2514.
2017
Mittal N, Guimaraes JC, Gross T, Schmidt A, Vina-Vilaseca A, Nedialkova DD, Aeschimann F, Leidel SA, Spang A, Zavolan M.
The Gcn4 Transcription Factor Reduces Protein Synthesis Capacity and Extends Yeast Lifespan.
Nature Communications 2017; 8(1): 457-468.
Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P, Jobst-Schwan T, Schmidt JM, Lawson JA, Schanze D, Ashraf S, Ullmann JFP, Hoogstraten CA, Boddaert N, Collinet B, Martin G, Liger D, Lovric S, Furlano M, Guerrera IC, Sanchez-Ferras O, Hu JF, Boschat AC, Sanquer S, Menten B, Vergult S, De Rocker N, Airik M, Hermle T, Shril S, Widmeier E, Gee HY, Choi WI, Sadowski CE, Pabst WL, Warejko J, Daga A, Basta-Leberre T, Matejas V, Scharmann K, Kienast SD, Behnam B, Beeson B, Begtrup A, Bruce M, Ch’ng GS, Lin SP, Chang JH, Chen CH, Cho MT, Gaffney PM, Gipson PE, Hsu CH, Kari JA, Ke YY, Kiraly-Borri C, Lai W, Lemyre E, Littlejohn RO, Masri A, Moghtaderi M, Nakamura K, Ozaltin F, Praet M, Prasad C, Prytula A, Roeder E, Rump P, Schnur RE, Shiihara T, Sinha M, Soliman NA, Soulami K, Sweetser DA, Tsai WH, Tsai JD, Topaloglu R, Vester U, Viskochil DH, Vatanavicharn N, Waxler JL, Wierenga KJ, Wolf MTF, Wong SN, Leidel SA, Truglio G, Dedon PC, Poduri A, Mane S, Lifton RP, Bouchard M, Kannu P, Chitayat D, Magen D, Calleweart B, van Tilbeurgh H, Zenker M, Antignac C & Hildebrandt F.
Mutations in the KEOPS complex genes cause nephrotic syndrome with primary microcephaly.
Nature Genetics 2017; 49(10): 1529-1538.
Leufken J, Niehues A, Sarin LP, Hippler M, Leidel SA**, Fufezan C**.
pyQms enables universal and accurate quantification of mass spectrometry data.
Molecular & Cellular Proteomics 2017; 16(10): 1736-1745.
Jakobsson ME, Małecki JM, Moen A, Nilges BS, Leidel SA, Falnes PO.
Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.
Nucleic Acids Research 2017; 45(14): 8239-8254.
Malecki J, Aileni V, Ho A, Nilges B, Moen A, Sørensen V, Schwarz J, Jakobsson M, Leidel SA, Falnes P.
The novel lysine specific methyltransferase METTL21B affects protein translation through inducible and dynamic methylation of Lys-165 in human eukaryotic elongation factor 1 alpha (eEF1A).
Nucleic Acids Research 2017; 45(8): 4370-4389.
Jungfleisch J, Nedialkova DD, Dotu I, Sloan KE, Martinez-Bosch N, Bruening L, Raineri E, Navarro P, Bohnsack MT, Leidel SA, Diez J.
A novel translational control mechanism involving RNA structures within coding sequences.
Genome Research 2017; 27(1): 95-106.
2016
Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Desmet CJ, Nguyen L, Leidel SA, Willis A, Buettner R, Chariot A, Close P.
Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Journal of Experimental Medicine 2016; 213(11): 2503-2523.
Iñigo S, Nagels Durand A, Ritter A, Le Gall S, Termathe M, Klassen R, Tohge T, De Coninck B, Van Leene J, De Clercq R, Cammue BPA, Fernie AR, Gevaert K, De Jaeger G, Leidel SA, Schaffrath R, Van Lijsebettens M, Pauwels L, Goossens A.
Glutaredoxin GRXS17 Associates with the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
Plant Physiology 2016; 172(2): 858-873.
Lecanda A, Nilges BS, Sharma P, Nedialkova DD, Schwarz J, Vaquerizas JM, Leidel SA.
Dual randomization of oligonucleotides to reduce the bias in ribosome-profiling libraries.
Methods 2016; 107: 89-97.
Paksa A, Bandemer J, Hoeckendorf B, Razin N, Tarbashevich K, Minina S, Meyen D, Biundo A, Leidel SA, Peyrieras N, Gov NS, Keller PJ, Raz E.
Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis.
Nature Communications 2016; 7(11288): 1-14.
Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel SA, Schöler HR, Seebohm G, Greber B.
Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ES Cells.
Cell Stem Cell 2016; 18(3): 341-353.
2015
Laguesse S, Creppe C, Nedialkova DD, Prévot PP, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L.
A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.
Developmental Cell 2015; 35(5): 553-567.
Nedialkova DD and Leidel SA.
Optimization of codon translation rates via tRNA modifications maintains proteome integrity.
Cell 2015; 161(7): 1606-1618.
Alings F, Sarin LP, Fufezan C, Drexler HCA, Leidel SA.
An evolutionary approach uncovers a diverse response of tRNA 2-thiolation to elevated temperatures in yeast.
RNA 2015; 21(2): 202-212.
2013
Fernández-Vázquez J, Vargas-Pérez I, Sansó M, Buhne K, Carmona M, Paulo E, Hermand D, Rodríguez-Gabriel M, Ayté J, Leidel S, Hidalgo E.
Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.
PLoS Genetics 2013; 9(7): e1003647.
Prior to 2010
Leslie Pedrioli DM, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW, Detmar M.
miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo.
Molecular and Cellular Biology 2010; 30(14): 3620-3634.
Leidel S*, Pedrioli P*, Bucher T, Brost R, Costanzo M, Schmidt A, Aebersold R, Boone C, Hofmann K, Peter M.
Ubiquitin-related modifier Urm1 acts as a sulfur-carrier in thiolation of eukaryotic tRNA.
Nature 2009; 458(7235): 228-232.
Strnad P, Leidel S, Vinogradova T, Euteneuer, U, Khodjakov A, Gönczy P.
Regulated HsSAS-6 levels ensure formation of a single procentriole per centrioles during the centrosome duplication cycle.
Developmental Cell 2007; 13(2): 203-213.
Leidel S, Delattre M, Cerutti L, Baumer K, Gönczy P.
SAS-6 defines a protein family required for centrosome duplication in elegans and in human cells.
Nature cell biology 2005; 7(2): 115-125.
Delattre M, Leidel S, Wani K, Baumer K, Bamat J, Schnabel H, Feichtinger R, Schnabel R, Gönczy P.
Centriolar SAS-5 is required for daughter centriole formation in elegans.
Nature cell biology 2004; 6(7): 656-664.
Leidel S and Gönczy P.
SAS-4 Is Essential for Centrosome Duplication in elegans and Is Recruited to Daughter Centrioles Once per Cell Cycle.
Developmental Cell 2003; 4(3): 431-439.
Tomilin A, Remenyi A, Lins K, Bak H, Leidel S, Vriend G, Wilmanns M, Schöler HR.
Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration.
Cell 2000; 103(6): 853-864.
Gönczy P, Echeverri G, Oegema K, Coulson A, Jones SJ, Copley RR, Duperon J, Oegema J, Brehm M, Cassin E, Hannak E, Kirkham M, Pichler S, Flohrs K, Goessen A, Leidel S, Alleaume AM, Martin C, Ozlu N, Bork P, Hyman AA.
Functional genomic analysis of cell division in elegans using RNAi of genes on chromosome III.
Nature 2000; 408(6810): 331-336.